- Title
- Histopathologic findings of autoimmunity in thyroid, pituitary, and adrenal diseases in chronic hepatitis C postmortem cases
- Creator
- Tran, Huy A.; Reeves, Glenn E. M.; Lyons, Tim J.; Attia, John R.
- Relation
- Endocrine Practice Vol. 16, Issue 4, p. 566-569
- Publisher Link
- http://dx.doi.org/10.4158/ep09359.or
- Publisher
- American Association of Clinical Endocrinologists
- Resource Type
- journal article
- Date
- 2010
- Description
- Objective: To assess the histologic prevalence of immune-mediated thyroid, pituitary, and adrenal diseases in postmortem cases with hepatitis C. Methods: We reviewed 108 consecutive cases of chronic hepatitis C in patients in whom a complete postmortem examination was performed. All microscopic and histologic slides of the thyroid, pituitary, and adrenal reports were reviewed and assessed for evidence of autoimmune diseases. These were compared with a control group of 100 postmortem cases without hepatitis C. Results: In chronic hepatitis C infection, there is a heightened immune response resulting in many autoimmune diseases. The commonest endocrinopathy in association with this chronic infection is thyroid disease, a finding confirmed in our current study. Among the 108 postmortem cases of hepatitis C, there were 14 cases (13%) with evidence of thyroiditis. No cases of pituitary or adrenal disease were found. The mean age of the patients was 52 years (range, 29 to 68). This frequency compared with 7 cases of thyroid disease (7%) in the control group (no significant difference between the 2 groups). Conclusion: On the basis of our postmortem data, thyroid disease was the only major endocrinopathy associated with hepatitis C infection, with a prevalence of 13%. This was comparable with other serologic and nonhistologic antemortem findings. There was no evidence of pituitary or adrenal involvement.
- Subject
- autoimmunity; hepatitis C; thyroid disease; pituitary diseases; adrenal diseases; patients
- Identifier
- http://hdl.handle.net/1959.13/931857
- Identifier
- uon:11187
- Identifier
- ISSN:1530-891X
- Language
- eng
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